• 货号：GA106408
• CAS号：524-95-8
• 分子式：C14H16BNO
• 分子量：225.09
• Beilstein号：2942273
• EC号：208-366-5
• MDL号：
• PubChem编号：24894325

属性
敏感性 光及湿度敏感
密度 1.0400
熔点 190-194°C
存贮条件 储存温度-20°C;充氩保存
描述
产品介绍 2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.
别名 二苯基硼酸2-氨基乙酯;2-氨基乙基二苯硼酸酯;2-氨基乙基联苯基硼酸酯;2-氨基乙酯二苯基硼酸;2-氨基乙基联苯基硼酸酯;二苯基硼酸;(2-Aminoethoxy)diphenylborane;2-Aminoethyl diphenyl borate;Diphenylboric acid 2-aminoethyl ester;2-APB
应用 用于黄酮类化合物的密度测定。膜渗透调控因子，调控细胞间IP3诱导的钙离子释放。