• 货号：GA139195
• CAS号：69-74-9
• 分子式：C9H13N3O5 · HCl
• 分子量：279.68
• Beilstein号：
• EC号：200-713-9
• MDL号：
• PubChem编号：24278329

属性
敏感性 易吸潮
存贮条件 储存温度2-8℃
描述
别名 1-(β-D-呋喃阿拉伯糖苷)-胞嘧啶 盐酸盐;Ara-C 盐酸盐;胞嘧啶阿拉伯糖苷 盐酸盐;阿拉伯糖胞嘧啶 盐酸盐;阿糖胞嘧啶 盐酸盐;阿糖胞苷 盐酸盐;胞嘧啶β-D-呋喃阿拉伯糖苷 盐酸盐;1-(β-D-Arabino-furanosyl)-cytosine hydrochloride; Ara-C hydrochloride; Arabinocytidine hydrochloride; Arabinosylcytosine hydrochloride; Cytarabine hydrochloride; Cytosine arabinoside hydrochloride; 1-(β-D-Arabino-furanosyl)-cytosine HCl; Cytarabine HCl
生化机理 Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway.Does not inhibit RNA synthesis. Anti-leukemia agent.