• 货号：GA159936
• CAS号：96829-58-2
• 分子式： C29H53NO5
• 分子量： 495.75
• Beilstein号：
• EC号：
• MDL号：
• PubChem编号：

属性

存贮条件 贮存温度2-8°C
描述

产品介绍 Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.
别名 ;N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl Ester; HY-B0218; Tetrahydrolipstatin; Ro-18-0647
生化机理 Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.
应用 Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。