紫杉醇 ,分析标准品,HPLC≥98%_33069-62-4_Paclitaxel

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中药标准品

紫杉醇 ,分析标准品,HPLC≥98%
货号：B23008 CAS号：33069-62-4

英文名：Paclitaxel

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产品货号	规格	货期	优惠价	数量
B23008-100mg	100mg	准现货	438.00
B23008-20mg	20mg	准现货	125.00

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货号：B23008
CAS号：33069-62-4
分子式：C₄₇H₅₁NO₁₄
分子量：853.91
Beilstein号：1420457
EC号：
MDL号：MFCD00869953
PubChem编号：24277878

属性

溶解性	Soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water.
存贮条件	储存温度2-8°C
熔点	213-216°C
密度	1.3900
旋光率	-49 ° (C=1, MeOH)
荧光	否
IC50	否
pK Values	否

描述

别名	Taxol
产品介绍	Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM
用途	有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。
生化机理	Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf

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