• 货号：GA134100
• CAS号：7081-44-9
• 分子式：C19H17ClN3O5SNa · H2O
• 分子量：457.86(as Anhydrous)
• Beilstein号：
• EC号：
• MDL号：
• PubChem编号：

属性
溶解性 Soluble in water (55 mg/ml at 25 °C), alcohol (1:30), methanol, ethanol (25 mg/ml at 25 °C), and DMSO (55 mg/ml at 25 °C).
存贮条件 储存温度2-8℃
描述
产品介绍 Cloxacillin Sodium是Cloxacillin的钠盐形式，是一种耐青霉素酶，耐酸，半合成的青霉素。
别名 邻氯苯唑西林钠;3,3-二甲基-6-[5-甲基-3-(2-氯苯基)-4-异唑甲酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠盐;邻氯苯甲异噁唑青霉素钠;邻氯苯甲异恶唑青霉素钠;邻氯青霉素;Sodium cloxacillin; (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt
生化机理 Cloxacillin is a semi-synthetic β-lactam antibiotic, related to penicillin, which suppresses the growth of gram-positive bacteria such as Staphylococcus by inhibiting the synthesis of peptidoglycan. Furthermore, cloxacillin inactivates the enzyme β-lactamase I, a side product produced by bacteria that are resistant to β-lactam antibiotics, by causing the acyl form of the enzyme to unfold. Escherichia coli containing plasmids carrying non-coding DsrA RNA are resistant to Cloxacilin. Cloxacillin sodium is an inhibitor of LACTB.
应用 A semi-synthetic antibiotic related to penicillin