• 货号：GA137236
• CAS号：433695-36-4
• 分子式：C9H12N2O4S
• 分子量：244.27
• Beilstein号：
• EC号：
• MDL号：
• PubChem编号：

属性
存贮条件 储存温度2-8°C
描述
产品介绍 BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.
别名 BRL-50481 ;BRL-50481
生化机理 BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).