冈田酸(软海绵酸) ,≥98.0%使用说明书与操作注意事项

产品货号	重量	货期	优惠价
G64991-50ug	50ug	准现货	1330.00
G64991-1mg	1mg	准现货	10800.00
G64991-25ug	25ug	准现货	800.00
G64991-500ug	500ug	准现货	7980.00

产品货号

重量

货期

优惠价

数量

G64991-50ug

50ug

准现货

1330.00

G64991-1mg

1mg

准现货

10800.00

G64991-25ug

25ug

准现货

800.00

G64991-500ug

500ug

准现货

7980.00

溶解性	Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (≥1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water
存贮条件	储存温度-20°C
密度	否
荧光	否
IC50	否
pK Values	否

溶解性

Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (≥1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water

存贮条件

储存温度-20°C

密度

否

荧光

否

IC50

否

pK Values

否

别名	OA;35-去甲基鳍藻毒素 1;OA;35-Demethyldinophysistoxin 1;35-Demethyl-DTX 1; 35-Demethyldinophysistoxin 1;Halochondrine A; 9,10-Deepithio-9,10-didehydroacanthifolicin
产品介绍	Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher concentrations (IC50= 10-15 nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not inhibited. This selectivity is the basis for an improved identification and quantification procedure for these enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC.
用途	An activator of PKC and inhibitor of PP1 and PP2A phosphatases;Okadaic Acid is a potent non-TPAtype tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein
生化机理	Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

别名

OA;35-去甲基鳍藻毒素 1;OA;35-Demethyldinophysistoxin 1;35-Demethyl-DTX 1; 35-Demethyldinophysistoxin 1;Halochondrine A; 9,10-Deepithio-9,10-didehydroacanthifolicin

产品介绍

Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher concentrations (IC50= 10-15 nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not inhibited. This selectivity is the basis for an improved identification and quantification procedure for these enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC.

用途

An activator of PKC and inhibitor of PP1 and PP2A phosphatases;Okadaic Acid is a potent non-TPAtype tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein

生化机理

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

标识符号	GHS06
信号词	Danger
危害声明	H301-H311-H315-H331
警示性声明	P261-P280-P301 + P310-P311
个人防护设备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RIDADR	否
WGK德国	3
闪点（华氏）	N/A
RTECS	AA8227800

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