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别名
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BChE
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产品介绍
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Butyrl Cholinesterase catalyzes the hydrolysis of a number of choline esters according to the following reaction:Acylcholine + H2O → choline + acidIt is a tetrameric glycoprotein with four subunits of equal size, each having a molecular weight of 110 kDa. Butyryl cholinesterase hydrolyzes butyrylcholine four times more rapidly than acetylcholine. Unlike acetyl cholinesterase, it does not hydrolyze D-≥-methyl acetylcholine. It is inhibited by 10-5 M physostigmine, numerous organophosphate esters, the carbamate derivates and quaternary ammonium salts.
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用途
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Selective inhibition of BChE activity can be used in the detection of organophosphates.Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents.Cholinesterases have also been investigated for their role in Alzheimer’s disease.
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生化机理
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Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities. BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+ and the activity is constant over the pH range 6.0-8.0. It is inhibited by Betaine, nicotine, organophosphates, carbamates.
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氢氧化铜，CP，95%
3,4-二甲氧基苯甲酸 9...
S-碘化丁酰硫代胆碱 98%
S-联萘酚 99%
α,α,α-三氟苯乙酮 99...
苯基三乙氧基硅烷 ,98%
苯甲醇 ,AR,≥99%
正辛酸 CP,98%
辛酸钠 99%
氯化镁，AR，98%
2-氨基-3-(三氟甲基)吡...
α-松油醇 ，GC≥96%
苯丁酸，AR,97%
4-硝基吲唑，97%
4-氯咪唑，97%
聚(4-苯乙烯磺酸钠)，av...
2-溴苯甲胺，98%
N-羟基正辛酰胺，98%
2,2 -双噻吩，98%
4,4 -二溴二苯甲酮，97...
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