Soluble in EtOH, acetone (50 mg/ml), DMSO (300 mg/ml), ethanol, and methanol. Insoluble in water
存贮条件
储存温度 2-8°C
熔点
84-100°C
密度
否
荧光
否
IC50
否
pK Values
否
描述
别名
Oligomycin
产品介绍
Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levels
用途
A specific inhibitor of the mitochondrial ATP-synthase.
生化机理
Macrolide antibiotic; inhibits mitochondrial ATPase and phosphoryl group transfer.
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