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生化机理
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Vinblastine does not interfere with phrenic nerve stimulation of rat diaphragm musculature in concentrations up to 200 microM. However, in relatively high doses, vinblastine (10-200 microM) produces an increase in baseline tension of diaphragm muscle. This effect is concentration related (EC50, approximately 88 microM), reversible, and independent of phrenic nerve stimulation. The elevation in baseline tension is unaffected by nAChR blockade via d-tubocurarine, but is dependent upon the presence of extracellular calcium. In human Burkitt lymphoma CA46 cells, vinblastine (IC50 values, 1.0 nM). It binds tubulin, thereby inhibiting the assembly of microtubules.It is used to treat certain kinds of cancer, including Hodgkin
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别名
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Vincaleukoblastine, Velban, Velsar;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-,meth;长春花碱;Vincaleukoblastine, Velban, Velsar;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-,meth
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L-薄荷醇 ,分析标准品,G...
维生素D3 ,分析标准品,H...
反丁烯二酸 ,分析标准品,H...
雌酮 ,>98.0%(GC)
伏格列波糖 ,分析标准品,H...
达卡巴嗪，分析标准品,HPL...
D-酪氨酸 ,分析标准品,H...
脱氢海罂粟碱 分析标准品,H...
儿茶素没食子酸，分析标准品,...
紫苏醛，分析标准品,HPLC...
Thonningianin ...
Thonningianin ...
Colutehydroqui...
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