Ruthenium red hinders cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to impede neurotransmitter release.In addition , Ruthenium red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Ruthenium red is an inhibitor of CaM and Troponin C.Ruthenium red is an inhibitor of Calcium Channel Protein, SERCA and TRPV.
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