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别名
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三羟黄酮; 黄芩苷元; 黄芩黄素; 黄芩甙元; 5,6,7-三羟基黄酮;5,6,7-Trihydroxyflavone
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产品介绍
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Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.
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用途
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An inhibitor of Ca2+ uptake, 5-LO, and 12-LO
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生化机理
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中药类黄酮的组成成分，黄芩的主要黄酮，抑制花生四烯酸代谢中的12-脂肪氧化酶路径（12-lipoxygenase ，12-LOX），此路径能抑制癌细胞的增殖，诱导凋亡途径。
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苯乙酮 ,≥99.0% (G...
扁桃苷 ,97%
丙酸 ,ACS reagen...
赤霉素 ,植物细胞培养级，≥...
硬脂酸钠 96%
单宁酸 ,AR
蒽 ,98%
二氢黄酮甙 ,97%
芳樟醇 ,98%
γ-亚麻酸甲酯 ≥98%
绿原酸，98% 
硬脂酸钠,99.5% 
肌醇,98%
香草酸，99%
阿拉伯树胶，颗粒
甜菊糖，95%
乙偶姻 ,97%,可能以晶形...
正癸酸 ,AR,99%
无水肌酸 ,98%
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